Multilocular sinonasal malignant melanoma: a poor prognostic subgroup?

Publication

Multilocular sinonasal malignant melanoma: a poor prognostic subgroup?

Journal Paper/Review - May 29, 2014

Stanimirov Rossi O, Vital Domenic, Soyka M B, Roth T N, Huber Gerhard, Holzmann D

Citation

Stanimirov Rossi O, Vital D, Soyka M, Roth T, Huber G, Holzmann D. Multilocular sinonasal malignant melanoma: a poor prognostic subgroup?. Eur Arch Otorhinolaryngol 2014; 272:123-9.

Type

Journal Paper/Review (English)

Journal

Eur Arch Otorhinolaryngol 2014; 272

Publication Date

May 29, 2014

Issn Electronic

1434-4726

Pages

123-9

Brief description/objective

Clinical observations show that two subtypes of sinonasal malignant melanoma exist: uni- and multilocular melanoma. The aim of this retrospective study was to determine the prevalence and outcome of multilocular sinonasal malignant melanoma. All patients with sinonasal malignant melanoma treated at our institution between 1992 and 2011 were included. Survival and recurrence data were analyzed related to the distribution pattern of the tumors and other factors. Twenty-five patients were identified and included in the analysis. Seven patients (28 %) suffered from multilocular, the remaining 18 patients (72 %) from unilocular sinonasal malignant melanoma. The first group showed a significantly worse disease-free survival, whereas disease-specific and overall survival did not differ between the two subtypes. Multilocular sinonasal malignant melanoma is associated with an unfavorable disease-free survival compared to its unilocular counterpart.