Publication
p16: A surrogate marker of high-risk human papillomavirus infection in squamous cell carcinoma of the nasal vestibule
Journal Paper/Review - Mar 28, 2017
Vital Domenic, Holzmann David, Huber Gerhard, Soyka Michael B, Moch Holger, Zimmermann Dieter R, Ikenberg Kristian
Units
PubMed
Doi
Citation
Type
Journal
Publication Date
Issn Electronic
Pages
Brief description/objective
BACKGROUND
The purpose of this study was to analyze the role of p16and the prevalence of human papillomavirus (HPV) in squamous cell carcinoma (SCC) of the nasal vestibule.
METHODS
Patients diagnosed from 1995 to 2014 were included in this study. Assessment of p16and HPV-DNA polymerase chain reaction (PCR) was performed and analyzed with respect to baseline, clinicopathological, and outcome parameters. The p16positivity was defined as unequivocal nuclear and cytoplasmic staining of ≥70% of the cells, whereas 50%-69% was considered to be a "borderline" result.
RESULTS
There were 46 patients with SCCs of the nasal vestibule, of whom 31 (67.4%) were available for p16and 30 (65.2%) for analysis of HPV. Expression of p16was present in 19.4% and showed coincidence with high-risk HPV (P < .001). Neither p16nor HPV-DNA had significant impact on outcome.
CONCLUSION
Significant immunoreactivity for p16was present in about one-fifth of the samples and figured as a surrogate marker of high-risk HPV infection. There was no influence on outcome.