Publication

PD-L1 is a positive prognostic factor in squamous cell carcinoma of the nasal vestibule

Journal Paper/Review - Feb 21, 2018

Units
PubMed
Doi

Citation
Vital D, Holzmann D, Huber G, Moch H, Morand G, Ikenberg K. PD-L1 is a positive prognostic factor in squamous cell carcinoma of the nasal vestibule. Rhinology 2018
Type
Journal Paper/Review (English)
Journal
Rhinology 2018
Publication Date
Feb 21, 2018
Issn Print
0300-0729
Brief description/objective

BACKGROUND
Aim was to analyse the role of PD-L1 in squamous cell carcinomas of the nasal vestibule. Advanced squamous cell carcinoma of the nasal vestibule is a highly aggressive tumour. The role of PD-L1 expression is unclear in this tumour type.

METHODOLOGY
Forty-six patients diagnosed between 1995 and 2014 were analyzed. Baseline characteristics and outcome were correlated to immunohistochemical staining of PD-L1. PD-L1 positivity of tumour cells and tumour infiltrating immune cells (TIIC) was defined by any staining of more than 1% of the tumour cells.

RESULTS
PD-L1 expression was interpretable in 31 of 46 patients (67.4%). PD-L1 positivity was present in 14 (45.2%) patients tumour cells and 17 (54.8%) patients TIIC. PD-L1 positivity of tumour cells was associated with a favourable disease free survival (p=0.019).

CONCLUSIONS
Positivity for PD-L1 in tumour cells is a prognostic factor in squamous cell carcinoma of the nasal vestibule and might enable a patient-tailored treatment.