Favorable Thrombolysis Outcome in Diabetic Stroke Patients treated with Metformin

Publication

Favorable Thrombolysis Outcome in Diabetic Stroke Patients treated with Metformin

Conference Paper/Poster - May 16, 2017

Westphal Laura Philine, Engelter Stefan T, Kägi Georg, Scherrer Michael, Leys Didier, Pezzini Alessandro, Turc Guillaume, Béjot Yannick, Padjen Visnja, Cautinho Jonathan, Zini Andrea, Heldner Mirjam, Eskandari Ashraf, Polymeris Alexandros, Nolte Christian, Curtze Sami, Hametner Christian, Wegener Susanne

Units

Neurologie

Keywords

Metformin, diabetes, stroke, thrombolysis

Citation

Westphal L, Engelter S, Kägi G, Scherrer M, Leys D, Pezzini A, Turc G, Béjot Y, Padjen V, Cautinho J, Zini A, Heldner M, Eskandari A, Polymeris A, Nolte C, Curtze S, Hametner C, Wegener S (2017). Favorable Thrombolysis Outcome in Diabetic Stroke Patients treated with Metformin.

Type

Conference Paper/Poster (English)

Conference Name

European Stroke Organisation Conference (ESOC) (-)

Publication Date

May 16, 2017

Brief description/objective

In this multicenter exploratory data analysis, we tested if pretreatment with Metformin positively affects outcome of thrombolysis in acute ischemic stroke patients with diabetes.

Stroke patients pretreated with Metformin receiving thrombolysis had less severe strokes on admission and better functional outcome at 3 months. The effect was Independent of other clinical differences between Metformin users and non-users, as determined by propensity score matching.

Patients with diabetes may benefit from Metformin treatment, particularly if they are at high risk of stroke.