WHO/EORTC classification of cutaneous lymphomas 2005: histological and molecular aspects

Publication

WHO/EORTC classification of cutaneous lymphomas 2005: histological and molecular aspects

Journal Paper/Review - Nov 1, 2005

Burg Günter, Kurrer Michael, Knobler Robert, Meijer Chris J L M, Pimpinelli Nicola, Ralfkiaer Elisabeth, Russell-Jones Robin, Sander Christian, Santucci Marco, Sterry Wolfram, Swerdlow Steven H, Vermeer Maarten H, Wechsler Janine, Kerl Helmut, Kazakov Dmitry V, Kempf Werner, Cozzio Antonio, Feit Josef, Willemze Rein, S Jaffe Elaine, Dummer Reinhard, Berti Emilio, Cerroni Lorenzo, Chimenti Sergio, Diaz-Perez José L, Grange Florent, Harris Nancy L, Whittaker Sean

Citation

Burg G, Kurrer M, Knobler R, Meijer C, Pimpinelli N, Ralfkiaer E, Russell-Jones R, Sander C, Santucci M, Sterry W, Swerdlow S, Vermeer M, Wechsler J, Kerl H, Kazakov D, Kempf W, Cozzio A, Feit J, Willemze R, S Jaffe E, Dummer R, Berti E, Cerroni L, Chimenti S, Diaz-Perez J, Grange F, Harris N, Whittaker S. WHO/EORTC classification of cutaneous lymphomas 2005: histological and molecular aspects. J Cutan Pathol 2005; 32:647-74.

Type

Journal Paper/Review (English)

Journal

J Cutan Pathol 2005; 32

Publication Date

Nov 1, 2005

Issn Print

0303-6987

Pages

647-74

Brief description/objective

UNLABELLED
The new WHO/EORTC classification for cutaneous lymphomas comprises mature T-cell and natural killer (NK)-cell neoplasms, mature B-cell neoplasms, and immature hematopoietic malignancies. It reflects the unique features of lymphoproliferative diseases of the skin, and at the same time it is as compatible as possible with the concepts underlying the WHO classification for nodal lymphomas and the EORTC classification of cutaneous lymphomas. This article reviews the histological, phenotypical, and molecular genetic features of the various nosological entities included in this new classification. These findings always have to be interpreted in the context of the clinical features and biologic behavior.

AIM
To review the histological, phenotypical and molecular genetic features of the various nosological entities of the new WHO/EORTC classification for cutaneous lymphomas.

METHODS
Extensive review of the literature cited in Medline and own data of the authors.

RESULTS
The WHO/EORTC classification of cutaneous lymphomas comprises mature T-cell and NK-cell neoplasms, mature B-cell neoplasms and immature hematopoietic malignancies. It reflects the unique features of primary cutaneous lymphoproliferative diseases.

CONCLUSION
This classification is as much as possible compatible with the concept of the WHO classification for nodal lymphomas and the EORTC classification of cutaneous lymphomas. The histological, phenotypical and molecular genetic features always have to be interpreted in the context of the clinical features and biologic behavior.