Publication

Standard and experimental therapy in cutaneous T-cell lymphomas

Journal Paper/Review - Feb 1, 2006

Units
PubMed
Doi

Citation
Dummer R, Cozzio A, Meier S, Beyeler M, Laetsch B, Doebbeling U, Urosevic M. Standard and experimental therapy in cutaneous T-cell lymphomas. J Cutan Pathol 2006; 33 Suppl 1:52-7.
Type
Journal Paper/Review (English)
Journal
J Cutan Pathol 2006; 33 Suppl 1
Publication Date
Feb 1, 2006
Issn Print
0303-6987
Pages
52-7
Brief description/objective

Cutaneous T-cell lymphomas are a heterogeneous group of lymphoproliferative disorders, characterized by the accumulation of clonal lymphocytes in the skin. Skin-directed therapies are the preferred first-line modalities. There are interesting new developments in topical therapy using retinoids and gene-therapy products such as adenovirus- interferon (IFN)-gamma. Systemic treatment uses biologicals such as fusion molecules, monoclonal antibodies and immune response modifiers (IFNs and retinoids), and well-tolerated antiproliferative drugs such as methotrexate. Evidence-based treatment recommendation exists but is hampered by the lack of large multicenter randomized trials.