Spindle-cell variant of primary cutaneous follicle center lymphoma spreading to the hepatobiliary tree, mimicking Klatskin tumor

Publication

Spindle-cell variant of primary cutaneous follicle center lymphoma spreading to the hepatobiliary tree, mimicking Klatskin tumor

Journal Paper/Review - Nov 20, 2012

Rozati Sima, Kerl Katrin, Kempf Werner, Tinguely Marianne, Zimmermann Dieter R, Dummer Reinhard, Cozzio Antonio

Citation

Rozati S, Kerl K, Kempf W, Tinguely M, Zimmermann D, Dummer R, Cozzio A. Spindle-cell variant of primary cutaneous follicle center lymphoma spreading to the hepatobiliary tree, mimicking Klatskin tumor. J Cutan Pathol 2012; 40:56-60.

Type

Journal Paper/Review (English)

Journal

J Cutan Pathol 2012; 40

Publication Date

Nov 20, 2012

Issn Electronic

1600-0560

Pages

56-60

Brief description/objective

Primary cutaneous follicle center lymphoma (pcFCL) is an indolent type of primary cutaneous B-cell lymphoma (pcBCL) rarely disseminating to other organs. PcBCL with spindle-cell morphology has been described as a rare variant of pcFCL but the prognosis data of this variant is sparse. We report a rare case of spindle-cell pcFCL with CD20(+), CD79a(+), CD3(+), Bcl-6(+), Mum-1(-) and CD10(-) tumor cells that infiltrated the hepatic hilum, mimicking a Klatskin tumor. On the basis of the sparse published data on spindle-cell morphology of pcBCL, this growth pattern should elicit awareness of an increased risk of systemic involvement in the otherwise indolent pcFCL.