No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels

Publication

No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels

Journal Paper/Review - Mar 13, 2012

Kovacs Peter, Pankow James S, Payne Felicity, Prokopenko Inga, Psaty Bruce M, Renström Frida, Rice Ken, Rotter Jerome I, Rybin Denis, Sandholt Camilla H, Sayer Avan A, Shrader Peter, North Kari E, Müller Gabriele, Kumari Meena, Kuusisto Johanna, Laakso Markku, Lecoeur Cécile, Lévy-Marchal Claire, Li Guo, Loos Ruth J F, Lyssenko Valeri, Marmot Michael, Marques-Vidal Pedro, Morken Mario A, Schwarz Peter E H, Siscovick David S, Stančáková Alena, Vollenweider Peter, Walker Mark, Watanabe Richard M, Pedersen Oluf, Meigs James B, Ingelsson Erik, Barroso Inês, Florez Jose C, Franks Paul W, Dupuis Josée, Wareham Nicholas J, Kao W H Linda, Groop Leif, Stumvoll Michael, Teslovich Tanya M, Waeber Gerard, Williams Gordon H, Witte Daniel R, Wood Andrew R, Xie Weijia, Boehnke Michael, Cooper Cyrus, Ferrucci Luigi, Froguel Philippe, Langenberg Claudia, Kivimäki Mika, Scott Robert A, Marek Diana, Rasmussen-Torvik Laura J, Stringham Heather M, Tanaka Toshiko, Aadahl Mette, Arking Dan E, Bergmann Sven, Boerwinkle Eric, Bonnycastle Lori L, Bornstein Stefan R, Brunner Eric, Lagou Vasiliki, Kutalik Zoltán, Chu Audrey Y, Grarup Niels, Manning Alisa K, Hivert Marie-France, Shungin Dmitry, Tönjes Anke, Yesupriya Ajay, Barnes Daniel, Bouatia-Naji Nabila, Glazer Nicole L, Jackson Anne U, Bumpstead Suzannah J, Brage Soren, Carlson Olga D, Gräßler Jürgen, Gustafsson Stefan, Hallmans Göran, Hansen Torben, Hingorani Aroon, Holloway John W, Hu Frank B, Isomaa Bo, Jameson Karen A, Johansson Ingegerd, Jonsson Anna, Goodarzi Mark O, Fox Caroline S, Chen Han, Chen Yii-Der Ida, Chines Peter S, Collins Francis S, Couper David J, Dennison Elaine M, Dowling Nicole F, Egan Josephine S, Ekelund Ulf, Erdos Michael R, Forouhi Nita G, Jørgensen Torben

Citation

Kovacs P, Pankow J, Payne F, Prokopenko I, Psaty B, Renström F, Rice K, Rotter J, Rybin D, Sandholt C, Sayer A, Shrader P, North K, Müller G, Kumari M, Kuusisto J, Laakso M, Lecoeur C, Lévy-Marchal C, Li G, Loos R, Lyssenko V, Marmot M, Marques-Vidal P, Morken M, Schwarz P, Siscovick D, Stančáková A, Vollenweider P, Walker M, Watanabe R, Pedersen O, Meigs J, Ingelsson E, Barroso I, Florez J, Franks P, Dupuis J, Wareham N, Kao W, Groop L, Stumvoll M, Teslovich T, Waeber G, Williams G, Witte D, Wood A, Xie W, Boehnke M, Cooper C, Ferrucci L, Froguel P, Langenberg C, Kivimäki M, Scott R, Marek D, Rasmussen-Torvik L, Stringham H, Tanaka T, Aadahl M, Arking D, Bergmann S, Boerwinkle E, Bonnycastle L, Bornstein S, Brunner E, Lagou V, Kutalik Z, Chu A, Grarup N, Manning A, Hivert M, Shungin D, Tönjes A, Yesupriya A, Barnes D, Bouatia-Naji N, Glazer N, Jackson A, Bumpstead S, Brage S, Carlson O, Gräßler J, Gustafsson S, Hallmans G, Hansen T, Hingorani A, Holloway J, Hu F, Isomaa B, Jameson K, Johansson I, Jonsson A, Goodarzi M, Fox C, Chen H, Chen Y, Chines P, Collins F, Couper D, Dennison E, Dowling N, Egan J, Ekelund U, Erdos M, Forouhi N, Jørgensen T. No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. Diabetes 2012; 61:1291-6.

Type

Journal Paper/Review (English)

Journal

Diabetes 2012; 61

Publication Date

Mar 13, 2012

Issn Electronic

1939-327X

Pages

1291-6

Brief description/objective

Gene-lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (β = 0.22 mmol/L [95% CI 0.13-0.31], P = 1.63 × 10(-6)). All SNPs were associated with 2-h glucose (β = 0.06-0.12 mmol/allele, P ≤ 1.53 × 10(-7)), but no significant interactions were found with PA (P > 0.18) or BMI (P ≥ 0.04). In this large study of gene-lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions.