Biological interpretation of genome-wide association studies using predicted gene functions

Publication

Biological interpretation of genome-wide association studies using predicted gene functions

Journal Paper/Review - Jan 19, 2015

Pers Tune H, Hirschhorn Joel N, Fehrmann Rudolf S N, Raychaudhuri Soumya, Boehnke Michael, Renström Frida, Speliotes Elizabeth K, Frayling Tim, Esko Tõnu, Gustafsson Stefan, Vedantam Sailaja, Lui Julian C, Yang Jian, Wood Andrew R, Westra Harm-Jan, Chan Yingleong, Karjalainen Juha M, Franke Lude

Citation

Pers T, Hirschhorn J, Fehrmann R, Raychaudhuri S, Boehnke M, Renström F, Speliotes E, Frayling T, Esko T, Gustafsson S, Vedantam S, Lui J, Yang J, Wood A, Westra H, Chan Y, Karjalainen J, Franke L. Biological interpretation of genome-wide association studies using predicted gene functions. Nat Commun 2015; 6:5890.

Type

Journal Paper/Review (English)

Journal

Nat Commun 2015; 6

Publication Date

Jan 19, 2015

Issn Electronic

2041-1723

Pages

5890

Brief description/objective

The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant gene sets for many phenotypes.