CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance

Publication

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance

Journal Paper/Review - Jan 14, 2005

Niess Jan Hendrik, Littman Dan R, Fox James G, Ploegh Hidde L, Boes Marianne, Vyas Jatin M, McCormick Beth A, Jung Steffen, Landsman Limor, Gu Xiubin, Brand Stephan, Reinecker Hans-Christian

Citation

Niess J, Littman D, Fox J, Ploegh H, Boes M, Vyas J, McCormick B, Jung S, Landsman L, Gu X, Brand S, Reinecker H. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 2005; 307:254-8.

Type

Journal Paper/Review (English)

Journal

Science 2005; 307

Publication Date

Jan 14, 2005

Issn Electronic

1095-9203

Pages

254-8

Brief description/objective

Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chemokine receptor CX3CR1 to form transepithelial dendrites, which enable the cells to directly sample luminal antigens. CX3CR1 was also found to control the clearance of entero-invasive pathogens by DCs. Thus, CX3CR1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.