Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma

Publication

Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma

Journal Paper/Review - May 1, 2016

Moreau Philippe, Ludwig Heinz, Driessen Christoph, Palumbo Antonio, Facon Thierry, Plesner Torben, Dimopoulos Meletios, Sondergeld Pia, Sonneveld Pieter, Zweegman Sonja, Einsele Hermann, van de Donk Niels W C J, San Miguel Jesús, Lokhorst Henk, Nahi Hareth, Ben-Yehuda Dina, Cavo Michele, Cook Gordon, Delforge Michel, Mateos Maria-Victoria

Citation

Moreau P, Ludwig H, Driessen C, Palumbo A, Facon T, Plesner T, Dimopoulos M, Sondergeld P, Sonneveld P, Zweegman S, Einsele H, van de Donk N, San Miguel J, Lokhorst H, Nahi H, Ben-Yehuda D, Cavo M, Cook G, Delforge M, Mateos M. Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma. Drugs 2016; 76:853-67.

Type

Journal Paper/Review (English)

Journal

Drugs 2016; 76

Publication Date

May 1, 2016

Issn Electronic

1179-1950

Pages

853-67

Brief description/objective

Monoclonal antibodies (mAbs) are a recent addition to multiple myeloma (MM) therapies and a number of mAbs directed at myeloma cell surface molecules are in development. Daratumumab is a CD38 mAb that has demonstrated substantial activity and good tolerability in four phase I, phase I/II and phase II studies as monotherapy, as well as in combination with current standard treatments in MM. The positive results obtained in the relapsed/refractory setting in patients with advanced-stage disease and in a small number of patients with newly diagnosed disease provide the rationale for the investigation of the agent in a number of ongoing phase III trials. mAbs are generally better tolerated than conventional chemotherapy; however, their use requires other special considerations. Such factors include those common to all mAbs, namely infusion-related reactions, but also factors that are observed with mAbs used in myeloma, such as interference with response assessment, or factors that are related to CD38 mAbs such as daratumumab, for instance blood typing interference. Our review provides an overview of the results from the daratumumab clinical trials conducted to date, as well as practical management considerations for the use of daratumumab based on our experience with the agent.