Mucocutaneous Ulcerations and Pancytopenia due to Methotrexate Overdose

Publication

Mucocutaneous Ulcerations and Pancytopenia due to Methotrexate Overdose

Journal Paper/Review - Nov 7, 2016

Knoll Katharina, Anzengruber Florian, Cozzio Antonio, French Lars E, Murer Carla, Navarini Alexander A

Citation

Knoll K, Anzengruber F, Cozzio A, French L, Murer C, Navarini A. Mucocutaneous Ulcerations and Pancytopenia due to Methotrexate Overdose. Case Rep Dermatol 2016; 8:287-293.

Type

Journal Paper/Review (English)

Journal

Case Rep Dermatol 2016; 8

Publication Date

Nov 7, 2016

Pages

287-293

Brief description/objective

UNASSIGNED
Methotrexate (MTX) is an antifolic drug used in the treatment of immune-mediated and neoplastic diseases. Initiation or dosage changes in MTX therapy can cause mucositis and bone marrow suppression. Skin lesions due to acute MTX toxicity are rare, but they serve as a herald for later-onset pancytopenia. Therefore, identification of those cutaneous lesions might help to initiate rescue strategies at an early stage. Here we describe a case with mucocutaneous ulcerations and pancytopenia due to overdosed MTX.