CXCR5-dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses

Publication

CXCR5-dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses

Journal Paper/Review - Dec 1, 2005

Junt Tobias, Fink Katja, Förster Reinhold, Senn Beatrice, Lipp Martin, Muramatsu Masamichi, Zinkernagel Rolf M, Ludewig Burkhard, Hengartner Hans

Units

Medizinisches Forschungszentrum, Institute of Immunobiology

PubMed

16301613

Citation

Junt T, Fink K, Förster R, Senn B, Lipp M, Muramatsu M, Zinkernagel R, Ludewig B, Hengartner H. CXCR5-dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses. Journal of immunology (Baltimore, Md. : 1950) 2005; 175:7109-16.

Type

Journal Paper/Review (English)

Journal

Journal of immunology (Baltimore, Md. : 1950) 2005; 175

Publication Date

Dec 1, 2005

Issn Print

0022-1767

Pages

7109-16

Brief description/objective

The chemokine receptor CXCR5 and its ligand CXCL13 define the structure of B cell follicles within secondary lymphoid organs. Here, we examined the impact of CXCR5 on antiviral B cell responses in vivo. CXCR5-/- mice showed a normal production of IgM and IgG acutely after infection with vesicular stomatitis virus (VSV) and developed VSV-specific germinal centers. However, impaired Ig class switch and Ab production were observed under conditions of limited availability of Ag (i.e., after immunization with nonreplicating viral particles or soluble Ag). Adoptive transfer of CXCR5-deficient, VSV-specific B and Th cells demonstrated that CXCR5 expression on both B and Th cells is required for an efficient Ig class switch. These experiments revealed that CXCR5 is critical for the coordinated interaction of antiviral T and B cells through its impact on initial B cell expansion and the recruitment of Ag-specific B and Th cells to germinal centers.