Critical Issues in Modelling Lymph Node Physiology

Publication

Critical Issues in Modelling Lymph Node Physiology

Journal Paper/Review - Dec 24, 2016

Grebennikov Dmitry, van Loon Raoul, Novkovic Mario, Onder Lucas, Savinkov Rostislav, Sazonov Igor, Tretyakova Rufina, J Watson Daniel, Bocharov Gennady

Units

Medizinisches Forschungszentrum, Institute of Immunobiology

Keywords

computational model, lymph node, multiscale structure, vascular network, fibroblastic reticular cells, conduit network, lymph flow, destruction of conduits

Citation

Grebennikov D, van Loon R, Novkovic M, Onder L, Savinkov R, Sazonov I, Tretyakova R, J Watson D, Bocharov G. Critical Issues in Modelling Lymph Node Physiology. Computation 2016; 5:3.

Type

Journal Paper/Review (English)

Journal

Computation 2016; 5

Publication Date

Dec 24, 2016

Issn Electronic

2079-3197

Publisher

MDPI AG (Basel, Switzerland)

Brief description/objective

In this study, we discuss critical issues in modelling the structure and function of lymph nodes (LNs), with emphasis on how LN physiology is related to its multi-scale structural organization. In addition to macroscopic domains such as B-cell follicles and the T cell zone, there are vascular networks which play a key role in the delivery of information to the inner parts of the LN, i.e., the conduit and blood microvascular networks. We propose object-oriented computational algorithms to model the 3D geometry of the fibroblastic reticular cell (FRC) network and the microvasculature. Assuming that a conduit cylinder is densely packed with collagen fibers, the computational flow study predicted that the diffusion should be a dominating process in mass transport than convective flow. The geometry models are used to analyze the lymph flow properties through the conduit network in unperturbed- and damaged states of the LN. The analysis predicts that elimination of up to 60%–90% of edges is required to stop the lymph flux. This result suggests a high degree of functional robustness of the network.