Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets

Publication

Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets

Journal Paper/Review - May 17, 2016

Saulite Ieva, Hoetzenecker Wolfram, Weidinger Stephan, Cozzio Antonio, Guenova Emmanuella, Wehkamp Ulrike

Citation

Saulite I, Hoetzenecker W, Weidinger S, Cozzio A, Guenova E, Wehkamp U. Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets. Biomed Res Int 2016; 2016:9717530.

Type

Journal Paper/Review (English)

Journal

Biomed Res Int 2016; 2016

Publication Date

May 17, 2016

Issn Electronic

2314-6141

Pages

9717530

Brief description/objective

Sézary syndrome (SS), an aggressive form of erythrodermic pruritic cutaneous T cell lymphoma (CTCL), from an immunological perspective characterized by increased Th2 cytokine levels, elevated serum IgE and impaired cellular immunity. Not only the clinical appearance but also the hallmark immunological characteristics of SS often share striking similarities with acute flares of atopic dermatitis (AD), a common benign chronic inflammatory skin disease. Given the overlap of several immunological features, the application of similar or even identical therapeutic approaches in certain stages of both diseases may come into consideration. The aim of this review is to compare currently accepted immunological aspects and possible therapeutic targets in AD and SS.