Publication

A population-based analysis of secondary malignancies in breast cancer patients receiving breast reconstruction

Journal Paper/Review - May 17, 2016

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Citation
Warschkow R, Cerny T, Schmied B, Gueller U, Thürlimann B, Joerger M. A population-based analysis of secondary malignancies in breast cancer patients receiving breast reconstruction. Br J Cancer 2016; 115:80-4.
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Type
Journal Paper/Review (English)
Journal
Br J Cancer 2016; 115
Publication Date
May 17, 2016
Issn Print
Issn Electronic
1532-1827
Pages
80-4
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Brief description/objective

BACKGROUND
There is an ongoing debate about the relationship between breast implants and secondary malignancies.

METHODS
Breast cancer patients undergoing surgical reconstruction after mastectomy by either implants or autologous flap were identified in the Surveillance, Epidemiology and End Results registry between 1998 and 2002. The occurrence of secondary malignancies at least 1 year after diagnosis was compared between breast reconstruction with implants vs autologous flap.

RESULTS
Of 7955 women, 3727 underwent reconstruction using implants and 4228 using autologous flap. The incidence of secondary tumours was similar in both the groups (hazards ratio (HR)=1.02, 95% confidence interval (CI): 0.82-1.26, P=0.880). For lung cancer, a significantly increased risk for implants (HR=2.51, 95% CI: 1.28-4.95, P=0.005) was observed.

CONCLUSIONS
Except for lung cancer, no association between implants and secondary malignancies including lymphomas was observed.