Advanced patient age at diagnosis of diffuse large B-cell lymphoma is associated with molecular characteristics including ABC-subtype and high expression of MYC

Publication

Advanced patient age at diagnosis of diffuse large B-cell lymphoma is associated with molecular characteristics including ABC-subtype and high expression of MYC

Journal Paper/Review - Aug 25, 2017

Paul Ulrike, Stein Harald, Hansmann Martin-Leo, Möller Peter, Szczepanowski Monika, Burkhardt Birgit, Pfreundschuh Michael, Schmitz Norbert, Loeffler Markus, Trümper Lorenz, Siebert Reiner, Cogliatti Sergio B., Feller Alfred C, Rosenwald Andreas, Richter Julia, Stuhlmann-Laiesz Christiane, Kreuz Markus, Nagel Inga, Horn Heike, Staiger Annette M, Aukema Sietse M, Hummel Michael, Ott German, Spang Rainer, Klapper Wolfram

Citation

Paul U, Stein H, Hansmann M, Möller P, Szczepanowski M, Burkhardt B, Pfreundschuh M, Schmitz N, Loeffler M, Trümper L, Siebert R, Cogliatti S, Feller A, Rosenwald A, Richter J, Stuhlmann-Laiesz C, Kreuz M, Nagel I, Horn H, Staiger A, Aukema S, Hummel M, Ott G, Spang R, Klapper W. Advanced patient age at diagnosis of diffuse large B-cell lymphoma is associated with molecular characteristics including ABC-subtype and high expression of MYC. Leuk Lymphoma 2017:1-9.

Type

Journal Paper/Review (English)

Journal

Leuk Lymphoma 2017

Publication Date

Aug 25, 2017

Issn Electronic

1029-2403

Pages

1-9

Brief description/objective

The incidence of diffuse large B-cell lymphoma (DLBCL) increases with age being patient age at diagnosis an adverse prognostic factor. However, elderly patients are often underrepresented in common studies. To investigate the effect between age and biological characteristics in DLBCL, we analyzed data of 1534 patients encompassing all adult age groups, enriched for the age ≥75 years. Follicular lymphoma (FL) grade 3B with histopathological characteristics of DLBCLs were included. Gender, centroblastic cytology, FL grade 3B morphology, CD10 expression, and ABC/non-GCB-subtype were significantly associated with age after correction for multiple testing and after adjusting for cohorts. Analysis of a subgroup points towards an association of MYC expression with age. Our data indicate that biological features of DLBCL and FL grade 3B are associated with increasing age among adult patients. The prevalence of the ABC/non-GCB-subtype in elderly patients suggests that therapies targeting this molecular subtype should be specifically explored in this subgroup.