Photodynamic endometrial ablation for the treatment of dysfuncional uterine bleeding: a preliminary report

Publication

Photodynamic endometrial ablation for the treatment of dysfuncional uterine bleeding: a preliminary report

Journal Paper/Review - Jan 15, 2004

Hornung René, Wagnières Georges, Steiner Rolf A., Tadir Yona, Schwarz Viola A., Fehr Mathias K., Mosimann Laurent, Gabrecht Tanja, Degen Andrea F., Wyss Pius

Citation

Hornung R, Wagnières G, Steiner R, Tadir Y, Schwarz V, Fehr M, Mosimann L, Gabrecht T, Degen A, Wyss P. Photodynamic endometrial ablation for the treatment of dysfuncional uterine bleeding: a preliminary report. Lasers in Surgery and Medicine 2004; 34:1-4.

Type

Journal Paper/Review (English)

Journal

Lasers in Surgery and Medicine 2004; 34

Publication Date

Jan 15, 2004

Pages

1-4

Brief description/objective

To evaluate feasibility and functional effects of photodynamic endometrial ablation (PEA) in patients.

Study Design/Patients and Methods

A total of 15 PEAs has been performed in 11 patients using topically applied 5-aminolevulinic acid (ALA) solutions and a balloon-light diffuser (160 J/cm2, 635 nm). Uterine bleeding intensity has been determined on a daily basis 3 months prior to and up to 6 months after endometrial ablation using an analogous scale scoring from 1 (spotting) to 6 U (severe bleeding). Statistical analysis by unpaired Student's t-test.

Results

The mean number of bleeding units per cycle (n = 44) was 35.7 prior to PEA. The decrease in bleeding units was significant for the months 1–3 (24.4 U per cycle; P = 0.03), but not for the months 4–6 (25.9 U; P = 0.11) following PEA.