Publication

Intrauterine light probe for photodynamic ablation therapy

Journal Paper/Review - Feb 1, 1999

Units
PubMed

Citation
Tadir Y, Hornung R, Pham T, Tromberg B. Intrauterine light probe for photodynamic ablation therapy. Obstet Gynecol 1999; 93:299-303.
Type
Journal Paper/Review (English)
Journal
Obstet Gynecol 1999; 93
Publication Date
Feb 1, 1999
Issn Print
0029-7844
Pages
299-303
Brief description/objective

BACKGROUND
Endometrial ablation by means of photodynamic therapy is currently being evaluated as an outpatient treatment for dysfunctional uterine bleeding. Photodynamic therapy requires the activation of a photosensitizer by laser light. We describe a new device specifically designed to provide light delivery to the uterus for endometrial photodynamic therapy.

INSTRUMENT
The intrauterine light probe consists of the three flexible optical fibers converging to one bundle resembling the shape of the uterine cavity. Each of the fibers contains a cylindrical light diffuser.

EXPERIENCE
The intrauterine light probe was tested in removed human uteri for its capability to distribute light in a tissue-simulating scattering medium and to deliver sufficient light throughout the endometrium. The light distribution of the intrauterine light probe in the scattering medium is uniform on eight axes tested around the diffusing fibers. The pattern of light distribution in human uteri is similar to that in the medium. At the endomyometrial junction, there is still one third of the light applied to the endometrial surface whereas deeper in the myometrium, the light power drops to less than 10%.

CONCLUSION
We propose a device that will deliver light to the uterine cavity to induce endometrial ablation by means of photodynamic therapy.