Publication
Association between androgen receptor expression, Ki-67 and the 21-gene recurrence score in non-metastatic, lymph node-negative, estrogen receptor-positive and HER2-negative breast cancer
Journal Paper/Review - Jun 15, 2015
Vera-Badillo Francisco E, Tannock Ian F, Bedard Philippe L, Goldstein Robyn, Seruga Bostjan, Templeton Arnoud, Ocana Alberto, Kuruzar Gordana, Chang Martin C, Amir Eitan
Units
PubMed
Doi
Citation
Type
Journal
Publication Date
Issn Electronic
Brief description/objective
BACKGROUND
The mechanisms underlying the favourable prognosis of androgen receptor (AR) expression in breast cancer are unknown.
METHODS
The associations between the 21-gene recurrence score (RS), AR, grade, mitotic score, Ki-67 and estrogen receptor (ER) and progesterone receptor (PgR) expression were explored in sequential women with lymph node-negative, ER-positive and HER2-negative breast cancer. Statistical significance of this exploratory study was defined as p<0.10.
RESULTS
Analysis comprised 70 women. Most tumours had high AR expression (97% had scores >3). Median RS was 15 (range 1-53). AR expression showed a minimally significant positive correlation with ER (R=0.37), but no correlation with Ki-67 (R=-0.18). In univariable analysis, AR (p=0.01), ER (p<0.001) and PgR (p<0.001) had significant negative associations with RS. Ki-67 (p=0.16), grade (p=0.40) and mitotic score (p=0.23) showed no association with RS. Multivariable analysis showed similar associations.
CONCLUSIONS
AR is associated with lower RS, but not with Ki-67.