Management of bone metastases in patients with castration-resistant prostate cancer

Publication

Management of bone metastases in patients with castration-resistant prostate cancer

Journal Paper/Review - Apr 30, 2014

Cathomas Richard, Tantawy Wahid, Pacik Dalibor, Milecki Piotr, Kramer Gero, Kacso Gabriel, Goncalves Frederico, Gillessen Sommer Silke, El Ghoneimy Ahmed, Bouzid Mounira, Bajory Zoltan, Lesniewski-Kmak Krzystof

Citation

Cathomas R, Tantawy W, Pacik D, Milecki P, Kramer G, Kacso G, Goncalves F, Gillessen Sommer S, El Ghoneimy A, Bouzid M, Bajory Z, Lesniewski-Kmak K. Management of bone metastases in patients with castration-resistant prostate cancer. Urol Int 2014; 92:377-86.

Type

Journal Paper/Review (English)

Journal

Urol Int 2014; 92

Publication Date

Apr 30, 2014

Issn Electronic

1423-0399

Pages

377-86

Brief description/objective

Bone metastases are a very common problem in prostate cancer. They are associated with considerable morbidity, adversely affect quality of life and frequently lead to advanced bone events (so-called skeletal-related events, SREs); SREs include fractures, spinal cord compression and the requirement for bone surgery or bone radiation. The aim of this paper was to evaluate currently available treatment options in the prevention and management of SREs and bone metastases in men with castration-resistant prostate cancer and to outline the importance of interdisciplinary management strategies. It also discusses the diagnostic workup of osseous metastases and practical considerations for the utilization of bone-targeted therapies in accordance with current guidelines to provide a consensus for special and/or difficult clinical situations.