Analgesic action of i.v. morphine-6-glucuronide in healthy volunteers

Publication

Analgesic action of i.v. morphine-6-glucuronide in healthy volunteers

Journal Paper/Review - Jan 1, 2000

Buetler T M, Wilder-Smith O H, Wilder-Smith C H, Aebi S, Cerny Thomas, Brenneisen R

Units

Medizinische Onkologie und Hämatologie

PubMed

10740556

Citation

Buetler T, Wilder-Smith O, Wilder-Smith C, Aebi S, Cerny T, Brenneisen R. Analgesic action of i.v. morphine-6-glucuronide in healthy volunteers. British journal of anaesthesia 2000; 84:97-9.

Type

Journal Paper/Review (English)

Journal

British journal of anaesthesia 2000; 84

Publication Date

Jan 1, 2000

Issn Print

0007-0912

Pages

97-9

Brief description/objective

The pharmacodynamics of morphine-6-glucuronide (M-6-G) i.v. were assessed in 12 healthy male volunteers in an open study. After a single bolus dose of M-6-G 5 mg i.v., we measured antinociceptive effects, using electrical and cold pain tests, and plasma concentrations of M-6-G, morphine-3-glucuronide (M-3-G) and morphine. Pain intensities during electrical stimulation (at 30, 60 and 90 min after injection) and ice water immersion (at 60 min) decreased significantly (P < 0.005) compared with baseline. Mean plasma peak concentrations of M-6-G were 139.3 (SD 38.9) ng ml-1, measured at 15 min. Our data demonstrate that M-6-G has significant analgesic activity.