Hepatitis B virus infection is associated with impaired immunological recovery during antiretroviral therapy in the Swiss HIV cohort study

Publication

Hepatitis B virus infection is associated with impaired immunological recovery during antiretroviral therapy in the Swiss HIV cohort study

Journal Paper/Review - Jul 30, 2013

Wandeler Gilles, Rauch Andri, Furrer Hansjakob, Egger Matthias, Calmy Alexandra, Battegay Manuel, Schmid Patrick, Kovari Helen, Cavassini Matthias, Bernasconi Enos, Bihl Florian, Gsponer Thomas, Swiss HIV Cohort Study

Citation

Wandeler G, Rauch A, Furrer H, Egger M, Calmy A, Battegay M, Schmid P, Kovari H, Cavassini M, Bernasconi E, Bihl F, Gsponer T, Swiss HIV Cohort Study. Hepatitis B virus infection is associated with impaired immunological recovery during antiretroviral therapy in the Swiss HIV cohort study. J Infect Dis 2013; 208:1454-8.

Type

Journal Paper/Review (English)

Journal

J Infect Dis 2013; 208

Publication Date

Jul 30, 2013

Issn Electronic

1537-6613

Pages

1454-8

Brief description/objective

Hepatitis B virus (HBV) infection is a major cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected patients worldwide. It is unclear whether HIV-related outcomes are affected by HBV coinfection. We compared virological suppression and immunological recovery during antiretroviral therapy (ART) of patients of different HBV serological status in the Swiss HIV Cohort Study. CD4 cell recovery during ART was significantly impaired in hepatitis B surface antigen-positive patients and in those with anti-hepatitis B core antigen alone compared with HBV-uninfected patients, despite similar virological efficacy of ART. CD4 increase in patients with resolved HBV infection was similar to that in HBV-uninfected individuals.