Publication
Current practice in neuropsychological outcome reporting after aneurysmal subarachnoid haemorrhage
Journal Paper/Review - Jul 26, 2013
Stienen Martin N., Schatlo Bawarjan, Schaller Karl, Bijlenga Philippe, Sailer Martin, Mondadori Christian, Brugger Peter, Monsch Andreas U, Bläsi Stefan, Gutbrod Klemens, Müri Rene, Studerus-Germann Aline, Hildebrandt Gerhard, Keller Emanuela, Fung Christian, Fandino Javier, Weisshaupt Rahel, on behalf of the Swiss SOS study group
Units
PubMed
Doi
Citation
Type
Journal
Publication Date
Issn Electronic
Brief description/objective
BACKGROUND
Neuropsychological deficits (NPD) are common in patients with aneurysmal subarachnoid haemorrhage (aSAH). NPD are one of the major limiting factors for patients with an otherwise acceptable prognosis for sustained quality of life. There are only a few studies reporting outcome after aSAH, which used a standardized neuropsychological test battery as a primary or secondary outcome measure. Aim of this study was to determine the current practice of reporting NPD following aSAH in clinical studies.
METHODS
A MEDLINE analysis was performed using the search term "subarachnoid haemorrhage outcome". The latest 1,000 articles were screened. We recorded study design, number of patients, and the presence of neuropsychological outcome report. Additionally, the time of testing after aSAH, the neuropsychological tests administered, as well as the percentage of patients with NPD were analyzed.
RESULTS
A total of 324 publications between 2009 and 2012 were selected for further review. Of those, 21 studies (6.5%) reported neuropsychological outcome, in 2,001 of 346,666 patients (0.6%). The assessment of NPD differed broadly using both subjective and objective cognitive evaluation, and a large variety of tests were used.
CONCLUSION
Neuropsychological outcome is underreported, and there is great variety in assessment in currently published clinical articles on aSAH. Prospective randomized trials treating aSAH may benefit from implementing more comprehensive and standardized neuropsychological outcome measures. This approach might identify otherwise unnoticed treatment effects in future interventional studies of aSAH patients.