Seroconversion to HCoV-NL63 in Rhesus Macaques

Publication

Seroconversion to HCoV-NL63 in Rhesus Macaques

Journal Paper/Review - Oct 30, 2009

Dijkman Ronald, Mulder H Lie, Rumping Lynne, Kraaijvanger Ilse, Deijs Martin, Jebbink Maarten F, Verschoor Ernst J, van der Hoek Lia

Citation

Dijkman R, Mulder H, Rumping L, Kraaijvanger I, Deijs M, Jebbink M, Verschoor E, van der Hoek L. Seroconversion to HCoV-NL63 in Rhesus Macaques. Viruses 2009; 1:647-56.

Type

Journal Paper/Review (English)

Journal

Viruses 2009; 1

Publication Date

Oct 30, 2009

Issn Electronic

1999-4915

Pages

647-56

Brief description/objective

HCoV-NL63 is a recently identified respiratory virus. Its pathogenesis has not been fully unraveled because an animal model is currently lacking. Here we examined whether rhesus macaques encounter HCoV-NL63 infections during life, by examining the levels of antibodies to HCoV-NL63 in time. The animals were followed for 7 up till 19 years, and in three animals we observed a steep rise in antibodies during follow up, indicative of a natural infection with HCoV-NL63.