Course of glial immunoreactivity for vimentin, tenascin and alpha1-antichymotrypsin after traumatic injury to human brain

Publication

Course of glial immunoreactivity for vimentin, tenascin and alpha1-antichymotrypsin after traumatic injury to human brain

Journal Paper/Review - Jan 1, 2001

Hausmann Roland, Betz P

Units

Rechtsmedizin

PubMed

11508799

Citation

Hausmann R, Betz P. Course of glial immunoreactivity for vimentin, tenascin and alpha1-antichymotrypsin after traumatic injury to human brain. Int J Legal Med 2001; 114:338-42.

Type

Journal Paper/Review (English)

Journal

Int J Legal Med 2001; 114

Publication Date

Jan 1, 2001

Issn Print

0937-9827

Pages

338-42

Brief description/objective

In a total of 104 individuals who had sustained traumatic brain injury (TBI), the course of glial immunoreactivity was investigated at the injured cortical area during the first 30 weeks after the trauma, in order to provide data for a forensic wound age estimation. Glial cells were stained with antibodies against the intermediate filament protein vimentin, the extracellular matrix protein tenascin and the serine protease inhibitor alpha1-antichymotrypsin (alpha1-ACT). Injury-induced glial staining reactions could be observed, at the earliest, after a post-infliction interval of 3.1 h for alpha1-ACT, 22 h for vimentin and 7 days for tenascin.