Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma

Publication

Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma

Journal Paper/Review - Jan 17, 2007

Semela David, Piguet Anne-Christine, Kolev Mirjam, Schmitter Karin, Hlushchuk Ruslan, Djonov Valentin, Stoupis Christoforos, Dufour Jean-François

Citation

Semela D, Piguet A, Kolev M, Schmitter K, Hlushchuk R, Djonov V, Stoupis C, Dufour J. Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma. J Hepatol 2007; 46:840-8.

Type

Journal Paper/Review (English)

Journal

J Hepatol 2007; 46

Publication Date

Jan 17, 2007

Issn Print

0168-8278

Pages

840-8

Brief description/objective

Hepatocellular carcinoma (HCC) is amenable to only few treatments. Inhibitors of the kinase mTOR are a new class of immunosuppressors already in use after liver transplantation. Their antiproliferative and antiangiogenic properties suggest that these drugs could be considered to treat HCC. We investigated the antitumoral effects of mTOR inhibition in a HCC model.