Eight months of continuous positive airway pressure (CPAP) decrease tumor necrosis factor alpha (TNFA) in men with obstructive sleep apnea syndrome

Publication

Eight months of continuous positive airway pressure (CPAP) decrease tumor necrosis factor alpha (TNFA) in men with obstructive sleep apnea syndrome

Journal Paper/Review - Mar 30, 2011

Hegglin Andrea, Schoch Otto, Korte Wolfgang, Hahn Kirsten, Hürny Christoph, Münzer Thomas

Citation

Hegglin A, Schoch O, Korte W, Hahn K, Hürny C, Münzer T. Eight months of continuous positive airway pressure (CPAP) decrease tumor necrosis factor alpha (TNFA) in men with obstructive sleep apnea syndrome. Sleep Breath 2011; 16:405-12.

Type

Journal Paper/Review (English)

Journal

Sleep Breath 2011; 16

Publication Date

Mar 30, 2011

Issn Electronic

1522-1709

Pages

405-12

Brief description/objective

OBJECTIVES
The aim of this study was to assess serum tumor necrosis factor alpha (TNFA) concentrations 8 months of continuous positive airway pressure (CPAP) therapy.

DESIGN
This study used prospective, observational clinical trial.

PATIENTS
Sixty-six patients with newly diagnosed sleep apnea syndrome (12 women, 54 men), age 52.3 ± 9.8 (mean ± SD) with a body mass index of 29.7 ± 4.4 and an apnea-hypopnea index of 39.7 ± 26.8, were studied.

INTERVENTION
CPAP was administered for a mean of 7.8 ± 1.3 months.

MEASUREMENTS AND RESULTS
TNFA concentrations using an ultrasensitive ELISA assay at baseline and follow-up. TNFA decreased in men with high (5.2 ± 1.7 h/night, -0.46 ± 1.1 ng/l, p = 0.001) and with low (2.5 ± 1.0 h/night -0.63 ± 0.77 ng/l, p = 0.001) adherence but not in women. Average number of hours of CPAP use correlated positively with delta TNFA (R (2) 0.08, p = 0.04)

CONCLUSION
Long-term CPAP positively affects TNFA even in men with poor adherence to CPAP.