Publication

The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses

Journal Paper/Review - Apr 27, 2011

Units
PubMed
Doi

Citation
Kuri T, Ziebuhr J, Thiel V, Siddell S, Davidson A, Snijder E, Züst R, Putics A, Eriksson K, Weber F. The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses. J Gen Virol 2011; 92:1899-905.
Type
Journal Paper/Review (English)
Journal
J Gen Virol 2011; 92
Publication Date
Apr 27, 2011
Issn Electronic
1465-2099
Pages
1899-905
Brief description/objective

Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1?-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to the antiviral effect of alpha interferon compared with their wild-type counterparts. The data suggest that macrodomain-associated ADRP activities may have a role in viral escape from the innate immune responses of the host.