Publication

Outcomes of antiretroviral therapy in the Swiss HIV Cohort Study: latent class analysis

Journal Paper/Review - Feb 1, 2012

Units
PubMed
Doi

Citation
Keiser O, Egger M, Ledergerber B, Nicca D, Glass T, Cavassini M, Calmy A, Rauch A, Spycher B, Swiss HIV Cohort Study. Outcomes of antiretroviral therapy in the Swiss HIV Cohort Study: latent class analysis. AIDS Behav 2012; 16:245-55.
Type
Journal Paper/Review (English)
Journal
AIDS Behav 2012; 16
Publication Date
Feb 1, 2012
Issn Electronic
1573-3254
Pages
245-55
Brief description/objective

An in-depth understanding of the different groups that make up the HIV-infected population should inform prevention and care. Using latent class analysis (LCA) we identified seven groups with similar socio-demographic and behavioral characteristics at enrolment in the Swiss HIV Cohort Study: older gay men, younger gay men, older heterosexual men, injection drug users, single migrants, migrant women in partnerships and heterosexual men and women. Outcomes of combination antiretroviral therapy (ART) were analyzed in 1,633 patients starting ART. Compared to older gay men, the probability of a virologic response to ART was reduced in single migrants, in older heterosexual men and in IDUs. Loss to follow-up was higher in single migrants and IDUs, and mortality was increased in older heterosexual men and IDUs. Socio-behavioral groups identified by LCA allow insights above what can be gleaned from traditional transmission groups, and may identify patients who could benefit from targeted interventions.