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Pneumocystis carinii pneumonia in chronic lymphocytic leukaemia

Journal Paper/Review - Apr 1, 2004

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Citation
Vavricka S, Halter J, Hechelhammer L, Himmelmann A. Pneumocystis carinii pneumonia in chronic lymphocytic leukaemia. Postgrad Med J 2004; 80:236-8.
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Type
Journal Paper/Review (English)
Journal
Postgrad Med J 2004; 80
Publication Date
Apr 1, 2004
Issn Print
0032-5473
Issn Electronic
Pages
236-8
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Brief description/objective

Pneumocystis carinii pneumonia in patients with chronic lymphocytic leukaemia (CLL) who have not been treated with fludarabin are rare, although clinically relevant CD4 T-cell depletion can occur in longstanding CLL without prior treatment with purine analogues. A 52 year old woman is reported who was on long term treatment with chlorambucil and taking a short course of prednisone for familial CLL before she developed progressive dyspnoea, and P carinii pneumonia was diagnosed in bronchoalveolar lavage fluid. Despite treatment with high dose co-trimoxazole the patient died.