Extra-osseous involvement of Langerhans' cell histiocytosis in children

Publication

Extra-osseous involvement of Langerhans' cell histiocytosis in children

Journal Paper/Review - Jan 23, 2004

Schmidt Sabine, Eich Georg, Hanquinet Sylviane, Tschäppeler Heinz, Waibel Peter, Gudinchet Francois

Citation

Schmidt S, Eich G, Hanquinet S, Tschäppeler H, Waibel P, Gudinchet F. Extra-osseous involvement of Langerhans' cell histiocytosis in children. Pediatr Radiol 2004; 34:313-21.

Type

Journal Paper/Review (English)

Journal

Pediatr Radiol 2004; 34

Publication Date

Jan 23, 2004

Issn Print

0301-0449

Pages

313-21

Brief description/objective

The predominant clinical and radiological features of Langerhans' cell histiocytosis (LCH) in children are due to osseous involvement. Extra-osseous disease is far less common, occurring in association with bone disease or in isolation; nearly all anatomical sites may be affected and in very various combinations. The following article is based on a multicentre review of 31 children with extra-osseous LCH. The objective is to summarise the diverse possibilities of organ involvement. The radiological manifestations using different imaging modalities are rarely pathognomonic on their own. Nevertheless, familiarity with the imaging findings, especially in children with systemic disease, may be essential for early diagnosis.