Prader-Willi syndrome is associated with activation of the innate immune system independently of central adiposity and insulin resistance

Publication

Prader-Willi syndrome is associated with activation of the innate immune system independently of central adiposity and insulin resistance

Journal Paper/Review - May 5, 2010

Viardot Alexander, Sze Lisa, Purtell Louise, Sainsbury Amanda, Loughnan Georgina, Smith Ellie, Herzog Herbert, Steinbeck Katharine, Campbell Lesley V

Citation

Viardot A, Sze L, Purtell L, Sainsbury A, Loughnan G, Smith E, Herzog H, Steinbeck K, Campbell L. Prader-Willi syndrome is associated with activation of the innate immune system independently of central adiposity and insulin resistance. J Clin Endocrinol Metab 2010; 95:3392-9.

Type

Journal Paper/Review (English)

Journal

J Clin Endocrinol Metab 2010; 95

Publication Date

May 5, 2010

Issn Electronic

1945-7197

Pages

3392-9

Brief description/objective

Subjects with Prader-Willi syndrome (PWS) have a reduced life expectancy due to cardiovascular disease. Increased systemic low-grade inflammation is postulated as a contributor, despite reported lower visceral fat mass and increased insulin sensitivity.