Publication

Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice

Journal Paper/Review - Mar 1, 2010

Units
PubMed
Doi

Citation
Lang P, Zinkernagel R, Ohashi P, Häussinger D, Harris N, Hengartner H, Ludewig B, Kalinke U, Van Rooijen N, Cervantes-Barragan L, Kulawik A, Meryk A, Krings C, Gailus N, Borkens S, Scheu S, Honke N, Recher M, Lang K. Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice. Hepatology 2010; 52:25-32.
Type
Journal Paper/Review (English)
Journal
Hepatology 2010; 52
Publication Date
Mar 1, 2010
Issn Electronic
1527-3350
Pages
25-32
Brief description/objective

The innate immune response plays an essential role in the prevention of early viral dissemination. We used the lymphocytic choriomeningitis virus model system to analyze the role of tissue macrophages/Kupffer cells in this process. Our findings demonstrated that Kupffer cells are essential for the efficient capture of infectious virus and for preventing viral replication. The latter process involved activation of Kupffer cells by interferon (IFN)-I and prevented viral spread to neighboring hepatocytes. In the absence of Kupffer cells, hepatocytes were not able to suppress virus replication, even in the presence of IFN-I, leading to prolonged viral replication and severe T cell-dependent immunopathology. Conclusion: Tissue-resident macrophages play a crucial role in early viral capture and represent the major liver cell type exhibiting responsiveness to IFN-I and providing control of viral replication. (HEPATOLOGY 2010).