Publication
C-reactive protein in the arterial intima: role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis
Journal Paper/Review - Sep 1, 2000
Torzewski Michael, Rist C, Mortensen R F, Zwaka T P, Bienek M, Waltenberger J, Koenig W, Schmitz G, Hombach V
PubMed
Citation
Type
Journal
Publication Date
Issn Electronic
Pages
Brief description/objective
Infiltration of monocytes into the arterial wall is an early cellular event in atherogenesis. Recent evidence shows that C-reactive protein (CRP) is deposited in the arterial intima at sites of atherogenesis. In this study, we demonstrate that CRP deposition precedes the appearance of monocytes in early atherosclerotic lesions. CRP is chemotactic for freshly isolated human blood monocytes. A specific CRP receptor is demonstrated on monocytes in vitro as well as in vivo, and blockage of the receptor by use of a monoclonal anti-receptor antibody completely abolishes CRP-induced chemotaxis. CRP may play a major role in the recruitment of monocytes during atherogenesis.