Publication

[Glioblastoma Multiforme - New Hope due to Modern Therapeutical Approaches.]

Journal Paper/Review - Mar 3, 2010

Units
PubMed
Doi

Citation
Gautschi O, Cadosch D, Collen T, Land M, Hoederath P, Hildebrandt G, Fournier J, Hundsberger T. [Glioblastoma Multiforme - New Hope due to Modern Therapeutical Approaches.]. Praxis (Bern 1994) 2010; 99:295-308.
Type
Journal Paper/Review (Deutsch)
Journal
Praxis (Bern 1994) 2010; 99
Publication Date
Mar 3, 2010
Issn Print
1661-8157
Pages
295-308
Brief description/objective

Glioblastoma multiforme (GBM) is the most frequently encountered malignant cerebral tumor. Despite significant improvements in the treatment of GBM, this disease remains associated with a high morbidity and mortality, with more than half of all affected patients dying within the first year after diagnosis. Typical symptoms include focal neurological symptoms, seizures, personality changes and neurocognitive symptoms. GBM can be identified by means of cerebral imaging modalities and subsequently confirmed histopathologically through biopsy or resection. At present, surgical resection followed by radiotherapy with concomitant chemotherapy with temozolomide and subsequent adjuvant chemotherapy with temozolomide is considered the standard therapy for patients with GBM. Currently, many interdisciplinary studies with glioblastoma patients are accomplished with the aim to further improve the prognosis of the affected patients.