Human coronavirus 229E encodes a single ORF4 protein between the spike and the envelope genes

Publication

Human coronavirus 229E encodes a single ORF4 protein between the spike and the envelope genes

Journal Paper/Review - Dec 28, 2006

Dijkman Ronald, Thiel Volker, Berkhout Ben, Franklin Sally, Minor Philip D, Zaaijer Hans L, Pyrc Krzysztof, Wilbrink Berry, Jebbink Maarten F, van der Hoek Lia

Citation

Dijkman R, Thiel V, Berkhout B, Franklin S, Minor P, Zaaijer H, Pyrc K, Wilbrink B, Jebbink M, van der Hoek L. Human coronavirus 229E encodes a single ORF4 protein between the spike and the envelope genes. Virol J 2006; 3:106.

Type

Journal Paper/Review (English)

Journal

Virol J 2006; 3

Publication Date

Dec 28, 2006

Issn Electronic

1743-422X

Pages

106

Brief description/objective

The genome of coronaviruses contains structural and non-structural genes, including several so-called accessory genes. All group 1b coronaviruses encode a single accessory protein between the spike and envelope genes, except for human coronavirus (HCoV) 229E. The prototype virus has a split gene, encoding the putative ORF4a and ORF4b proteins. To determine whether primary HCoV-229E isolates exhibit this unusual genome organization, we analyzed the ORF4a/b region of five current clinical isolates from The Netherlands and three early isolates collected at the Common Cold Unit (CCU) in Salisbury, UK.