Publication

Concordant colon tumors in monozygotic twins previously treated for prostate cancer

Journal Paper/Review - Jan 1, 2009

Units
PubMed
Doi

Citation
Templeton A, Marra G, Valtorta E, Heinimann K, Müller H, Köberle D, Gillessen Sommer S. Concordant colon tumors in monozygotic twins previously treated for prostate cancer. Familial cancer 2009; 8:167-71.
Type
Journal Paper/Review (English)
Journal
Familial cancer 2009; 8
Publication Date
Jan 1, 2009
Issn Electronic
1573-7292
Pages
167-71
Brief description/objective

This report describes the quasi-simultaneous occurrence of colon cancers in monozygotic twin brothers (age 63 years) who had undergone androgen deprivation therapy for prostate cancers 4 years earlier. Concordance among male twins for both of these cancers has never been reported. Although the family history suggested possible genetic predispositions to both cancers, the twins have no evidence of the genetic alterations associated with hereditary colorectal tumors. We explore the possibility that colorectal tumorigenesis in these twins was fuelled by a combination of genetic and iatrogenic factors, in particular the androgen deprivation therapy used to treat their prostate cancers.