Publication

[Paraneoplastic retinopathy in 2 patients with breast carcinoma]

Journal Paper/Review - Jan 1, 1997

Units
PubMed

Citation
Huober J, Holz F, Schmid H, Nölle B, Bellmann C, Krastel H, Wallwiener D, Bastert G. [Paraneoplastic retinopathy in 2 patients with breast carcinoma]. Zentralblatt für Gynäkologie 1997; 119:278-81.
Type
Journal Paper/Review (Deutsch)
Journal
Zentralblatt für Gynäkologie 1997; 119
Publication Date
Jan 1, 1997
Issn Print
0044-4197
Pages
278-81
Brief description/objective

Paraneoplastic retinopathies are rare paraneoplastic phenomena resulting in retinal degeneration. They occur in association with different tumor types, yet most frequently encountered in small cell carcinoma of the lung. Clinical symptoms may be present before the diagnosis of the underlying malignancy. They are characterized clinically by progressive visual loss with ring scotomas, photopsia and night-blindness. An autoimmune disorder is suggested. In the sera of patients antiretinal antibodies may be detected that are sometimes reactive with the 23 kD retinal antigen recoverin, a photoreceptorprotein. We report on two patients with breast cancer who developed paraneoplastic retinopathy during the course of disease. Immunologic tests showed antiretinal antibodies that were not reactive with the 23 kD retinal antigen recoverin.