Publication

A mathematical approach for optimizing dendritic cell-based immunotherapy

Journal Paper/Review - Jan 1, 2005

Units
PubMed

Citation
Bocharov G, Ford N, Ludewig B. A mathematical approach for optimizing dendritic cell-based immunotherapy. Methods in molecular medicine 2005; 109:19-34.
Type
Journal Paper/Review (English)
Journal
Methods in molecular medicine 2005; 109
Publication Date
Jan 1, 2005
Issn Print
1543-1894
Pages
19-34
Brief description/objective

Adoptive dendritic cell (DC)-based immunotherapy represents a promising approach to overcome peripheral tolerance against autologous tumor antigens and to maintain protective antitumor immunity. The translation of successful preclinical studies, however, appears to be hampered by new complexities associated with the clinical situation. Mathematical modeling provides the means for qualitative and quantitative analysis, predictions for complex dynamic systems in immunology, and for the design and improvement of therapeutic approaches. We present here a workable computational methodology for developing meaningful data- and hypothesis-driven mathematical models for DC-based immunotherapy with a particular focus on numerical parameter estimation and sensitivity analysis.