Publication

Midregional pro-A-type natriuretic peptide for the evaluation of exercise intolerance

Journal Paper/Review - Dec 22, 2009

Units
PubMed
Doi

Citation
Maeder M, Bergmann A, Morgenthaler N, Reichlin T, Potocki M, Schaub N, Breidthardt T, Noveanu M, Staub D, Christ A, Brutsche M, Mueller C. Midregional pro-A-type natriuretic peptide for the evaluation of exercise intolerance. International journal of cardiology 2009
Type
Journal Paper/Review (English)
Journal
International journal of cardiology 2009
Publication Date
Dec 22, 2009
Issn Electronic
1874-1754
Brief description/objective

The aim of this study was to determine the accuracy of midregional pro-A-type natriuretic peptide (MR-proANP) for the identification of a cardiocirculatory exercise limitation (CL) as assessed by cardiopulmonary exercise testing (CPET) and to compare it to B-type natriuretic peptide (BNP). Among 94 patients with CPET data fulfilling criteria for appropriate effort and sufficient diagnostic certainty, 27 (29%) had CL. The areas under the receiver-operator-characteristic curve for MR-proANP and BNP to identify CL were 0.84 and 0.79 respectively (p=0.17). In conclusion, MR-proANP had a comparable accuracy to BNP for the identification of CL and might be a valuable assistance for the differentiation of exercise intolerance.