Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study

Publication

Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study

Journal Paper/Review - Jan 11, 2010

Rauch Andri, Hirschel Bernard, Malinverni Raffaele, Moradpour Darius, Mullhaupt Beat, Witteck Andrea, Beckmann Jacques S, Berg Thomas, Bergmann Sven, Negro Francesco, Telenti Amalio, Bochud Pierre-Yves, Swiss Hepatitis C Cohort Study, Heim Markus, Günthard Huldrych F, Furrer Hansjakob, Kutalik Zoltán, Descombes Patrick, Cai Tao, di Iulio Julia, Mueller Tobias, Bochud Murielle, Battegay Manuel, Bernasconi Enos, Borovicka Jan, Colombo Sara, Cerny Andreas, Dufour Jean-François, Swiss HIV Cohort Study

Citation

Rauch A, Hirschel B, Malinverni R, Moradpour D, Mullhaupt B, Witteck A, Beckmann J, Berg T, Bergmann S, Negro F, Telenti A, Bochud P, Swiss Hepatitis C Cohort Study, Heim M, Günthard H, Furrer H, Kutalik Z, Descombes P, Cai T, di Iulio J, Mueller T, Bochud M, Battegay M, Bernasconi E, Borovicka J, Colombo S, Cerny A, Dufour J, Swiss HIV Cohort Study. Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. Gastroenterology 2010; 138:1338-45, 1345.e1-7.

Type

Journal Paper/Review (English)

Journal

Gastroenterology 2010; 138

Publication Date

Jan 11, 2010

Issn Electronic

1528-0012

Pages

1338-45, 1345.e1-7

Brief description/objective

Hepatitis C virus (HCV) induces chronic infection in 50% to 80% of infected persons; approximately 50% of these do not respond to therapy. We performed a genome-wide association study to screen for host genetic determinants of HCV persistence and response to therapy.