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Alterations of the thoracic spine in Marfan's syndrome

Journal Paper/Review - May 1, 2006

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Citation
Daeubler B, Carrel T, Kujawski T, Schnyder A, Zurmühle P, Vock P, Anderson S. Alterations of the thoracic spine in Marfan's syndrome. AJR. American journal of roentgenology 2006; 186:1246-51.
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Type
Journal Paper/Review (English)
Journal
AJR. American journal of roentgenology 2006; 186
Publication Date
May 1, 2006
Issn Print
Issn Electronic
1546-3141
Pages
1246-51
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Brief description/objective

OBJECTIVE: The purpose of this study was to determine if the thoracic vertebral elements are altered in patients with Marfan's syndrome. MATERIALS AND METHODS: Thirty patients underwent helical CT of the thorax because of suspected thoracic aortic dilatation and acute dissection. Thirteen had Marfan's syndrome and 17 did not. Two reviewers, unaware of the final diagnosis, evaluated the images by consensus for laminar thickness, foraminal width, dural sac ratios, and vertebral scalloping for T2-T12. RESULTS: At T9-T12, dural sac ratios at the midcorpus level (p = 0.031) and foraminal width (p = 0.0124) were significantly greater in the patients with Marfan's syndrome than in the patients without. Dural sac ratios at lower endplate levels (p = 0.0685), laminar thickness (p = 0.951), and vertebral scalloping (p = 0.24) were not significantly greater in the patients with Marfan's syndrome than in the patients without. CONCLUSION: Because the phenotypic expression of Marfan's syndrome is variable, information on the spine from thoracic studies in combination with major criteria may be helpful clinically.