Publication
Postprandial cardiac autonomic function in prader-willi syndrome
Journal Paper/Review - Oct 26, 2012
Purtell Louise, Campbell Lesley V, Steinbeck Katharine, Loughnan Georgina, Smith Arabella, Sainsbury Amanda, Herzog Herbert, Viardot Alexander, Jenkins Arthur, Sze Lisa
Units
PubMed
Doi
Citation
Type
Journal
Publication Date
Issn Electronic
Brief description/objective
CONTEXT: Individuals with Prader-Willi syndrome (PWS) have a high cardiovascular risk, the mechanism of which is unclear. There may be dysfunction in the autonomic nervous system in PWS. OBJECTIVE: To measure, as indicators of cardiac autonomic function, postprandial heart rate variability (HRV) and arterial stiffness in adults with PWS. METHODS: 10 adults with PWS were compared with 11 matched healthy obese subjects and 9 healthy lean subjects. Electrocardiographic traces and arterial stiffness were recorded over a period of 10 minutes at -60, 0, 30, 60, 120 and 240 minutes after consumption of a standardised 600 kCal breakfast. Frequency domain analysis was performed using Fast Fourier Transform to estimate power spectral density in the full spectrum and in low frequency (LF 0.04 - 0.15 Hz) and high frequency (HF 0.15 - 0.40 Hz) bands. RESULTS: ANCOVA analysis revealed a reduced low-frequency (LF) HRV meal response in PWS compared to obese controls, with no differences in high-frequency (HF) HRV, LF/HF ratio, heart rate, total power or arterial stiffness meal responses. CONCLUSIONS: The current study assesses cardiac autonomic function in PWS compared with matched obese and lean in response to a meal. Results suggest impaired postprandial autonomic nervous system responsiveness in PWS, which could contribute to both the known increased cardiovascular risk and obesity. © 2012 Blackwell Publishing Ltd.