[Long-term therapy of Ménétrier disease using ranitidine and pirenzepine]

Publication

[Long-term therapy of Ménétrier disease using ranitidine and pirenzepine]

Journal Paper/Review - Jun 8, 1991

Meyenberger Christa, Altorfer J, Münch R, Muller A, Ammann R

Units

Gastroenterology/Hepatology

PubMed

1857946

Citation

Meyenberger C, Altorfer J, Münch R, Muller A, Ammann R. [Long-term therapy of Ménétrier disease using ranitidine and pirenzepine]. Schweizerische medizinische Wochenschrift 1991; 121:877-80.

Type

Journal Paper/Review (Deutsch)

Journal

Schweizerische medizinische Wochenschrift 1991; 121

Publication Date

Jun 8, 1991

Issn Print

0036-7672

Pages

877-80

Brief description/objective

A 22-year-old woman with hypertrophic protein-losing gastropathy (Ménétrier's disease) is described. During treatment with ranitidine (Zantic) and pirenzepine (Gastrozepin) the gastric mucosa and protein loss were normalized within 4 years. Clinical and histological remission has now been observed for 5 and 3 years respectively. In a 57-year-old woman with hypertrophic gastropathy, 8 months' treatment with ranitidine and pirenzepine was associated with decrease in protein loss and improvement of the histological appearance of the gastric mucosa after one year. Long-term treatment of hypertrophic gastropathy with ranitidine and/or pirenzepine should, therefore, be considered in such cases instead of gastrectomy.