Chlorpromazine-induced vanishing bile duct syndrome leading to biliary cirrhosis

Publication

Chlorpromazine-induced vanishing bile duct syndrome leading to biliary cirrhosis

Journal Paper/Review - Dec 1, 1994

Moradpour D, Altorfer J, Flury R, Greminger Peter, Meyenberger Christa, Jost R, Schmid M

Units

Allgemeine Innere Medizin | Hausarztmedizin und Notfallmedizin, Gastroenterology/Hepatology

PubMed

7982642

Citation

Moradpour D, Altorfer J, Flury R, Greminger P, Meyenberger C, Jost R, Schmid M. Chlorpromazine-induced vanishing bile duct syndrome leading to biliary cirrhosis. Hepatology (Baltimore, Md.) 1994; 20:1437-41.

Type

Journal Paper/Review (English)

Journal

Hepatology (Baltimore, Md.) 1994; 20

Publication Date

Dec 1, 1994

Issn Print

0270-9139

Pages

1437-41

Brief description/objective

We describe a 33-yr-old pregnant woman in whom a primary biliary cirrhosis-like syndrome developed after 2 wk of chlorpromazine therapy. The clinical course was characterized by severe jaundice lasting 22 mo, intense pruritus, fever, steatorrhea, high alkaline phosphatase levels and hypercholesterolemia. Jaundice resolved with initiation of ursodeoxycholic acid therapy, but subclinical cholestasis and low-level inflammatory activity persisted and ultimately evolved into biliary cirrhosis. The pathological substrate of this severe and prolonged cholestatic reaction was found to be the vanishing bile duct syndrome with a marked transient pseudoxanthomatosis.