Long-term outcome of acute myocarditis is independent of cardiac enzyme release

Publication

Long-term outcome of acute myocarditis is independent of cardiac enzyme release

Journal Paper/Review - Jun 1, 2003

Ammann Peter, Naegeli Barbara, Schuiki Ernst, Straumann Edwin, Frielingsdorf Jürgen, Rickli Hans, Bertel Osmund

Units

Kardiologie

PubMed

12767545

Citation

Ammann P, Naegeli B, Schuiki E, Straumann E, Frielingsdorf J, Rickli H, Bertel O. Long-term outcome of acute myocarditis is independent of cardiac enzyme release. International journal of cardiology 2003; 89:217-22.

Type

Journal Paper/Review (English)

Journal

International journal of cardiology 2003; 89

Publication Date

Jun 1, 2003

Issn Print

0167-5273

Pages

217-22

Brief description/objective

BACKGROUND: There are few data concerning prognostic markers of acute myocarditis. The purpose of this study was to assess the prognostic value of initial measurements of creatine kinase (CK), cardiac troponin I (cTnI) and myoglobin as regards late recovery of the left ventricular ejection fraction on follow-up. METHODS: A total of 22 patients (53+/-15 years old, 11 female) with acute myocarditis were followed up in a prospective observational study. Of these, 11 (50%) showed a history of acute infection prior to hospitalisation and seven (32%) had pericardial effusion. The median ejection fraction during the acute phase was 47+/-17%; after a mean follow-up of 119+/-163 days it improved to 60+/-9% (P<0.001). Considering maximal CK-rise values of 641+/-961 U/l (P=0.38), cTnI-rise values of 3.7+/-8.6 microg/l (P=0.16) and myoglobin values of 7.4+/-12 nmol/l (P=0.69), there was no correlation between initial cardiac enzyme levels and the initial and late left ventricular ejection fraction. CONCLUSION: After acute myocarditis, there is late recovery of left ventricular ejection fraction, which is independent of the initial myocardial damage measured by cardiac enzyme release.