Antigen kinetics determines immune reactivity

Publication

Antigen kinetics determines immune reactivity

Journal Paper/Review - Apr 1, 2008

Johansen Pål, Bot Adrian, Speck Roberto F, Gerlach Tilman, Mullhaupt Beat, Senti Gabriela, Lang Karl S, Manolova Vania, Smith Kent A, Der-Sarkissian Ani, Qiu Zhiyong, Rettig Lorna, Storni Tazio, Kündig Thomas M

Citation

Johansen P, Bot A, Speck R, Gerlach T, Mullhaupt B, Senti G, Lang K, Manolova V, Smith K, Der-Sarkissian A, Qiu Z, Rettig L, Storni T, Kündig T. Antigen kinetics determines immune reactivity. Proceedings of the National Academy of Sciences of the United States of America 2008; 105:5189-94.

Type

Journal Paper/Review (English)

Journal

Proceedings of the National Academy of Sciences of the United States of America 2008; 105

Publication Date

Apr 1, 2008

Issn Electronic

1091-6490

Pages

5189-94

Brief description/objective

A current paradigm in immunology is that the strength of T cell responses is governed by antigen dose, localization, and costimulatory signals. This study investigates the influence of antigen kinetics on CD8 T cell responses in mice. A fixed cumulative antigen dose was administered by different schedules to produce distinct dose-kinetics. Antigenic stimulation increasing exponentially over days was a stronger stimulus for CD8 T cells and antiviral immunity than a single dose or multiple dosing with daily equal doses. The same was observed for dendritic cell vaccination, with regard to T cell and anti-tumor responses, and for T cells stimulated in vitro. In conclusion, stimulation kinetics per se was shown to be a separate parameter of immunogenicity. These findings warrant a revision of current immunization models and have implications for vaccine development and immunotherapy.