[Immunoglobulin therapy for systemic lupus erythematosus]

Publication

[Immunoglobulin therapy for systemic lupus erythematosus]

Journal Paper/Review - Apr 1, 1993

Utku N, von Kempis Johannes, Rockstroh J K, Sauerbruch T

Units

Rheumatologie

PubMed

8344681

Citation

Utku N, von Kempis J, Rockstroh J, Sauerbruch T. [Immunoglobulin therapy for systemic lupus erythematosus]. Immunität und Infektion 1993; 21 Suppl 1:26-7.

Type

Journal Paper/Review (Deutsch)

Journal

Immunität und Infektion 1993; 21 Suppl 1

Publication Date

Apr 1, 1993

Issn Print

0340-1162

Pages

26-7

Brief description/objective

A 25-year-old patient with lupus erythematosus was admitted with myositis and erythema of the skin under chloroquine therapy. After improvement of clinical symptoms with cyclophosphamide and prednisolone he was again progredient with myositis. The changing of therapy to methotrexate showed a hepatotoxic side effect with elevated liver enzymes. Under subsequent therapy with azathioprine and prednisolone he developed leukopenia and sepsis. Because of persistent erythema of the skin under therapy with different immunosuppressives we performed a therapy with high-dose intravenous immunoglobulins. After application of immunoglobulins we observed an improvement of the erythema after 10 days, which was persistent after dose reduction for about 4 months.