Publication

Role of cholecystokinin as a regulator of solid and liquid gastric emptying in humans

Journal Paper/Review - Sep 1, 1996

Units
PubMed

Citation
Borovicka J, Fried M, Delaloye A, D'Amato M, Jansen J, Read N, Wells A, Mettraux C, Rémy B, Asal K, Kreiss C, Schwizer W. Role of cholecystokinin as a regulator of solid and liquid gastric emptying in humans. The American journal of physiology 1996; 271:G448-53.
Type
Journal Paper/Review (English)
Journal
The American journal of physiology 1996; 271
Publication Date
Sep 1, 1996
Issn Print
0002-9513
Pages
G448-53
Brief description/objective

The role of endogenous cholecystokinin (CCK) in the regulation of gastric emptying remains controversial. We therefore studied the effect of the CCK-A receptor antagonist loxiglumide on gastric emptying of a high-caloric solid-liquid meal in humans. Gastric emptying was assessed in eight volunteers using intravenous loxiglumide or placebo in a randomized double-blind order. Subjects were studied by a dual-headed gamma camera after ingestion of a pancake (570 kcal) labeled with 99mTc-sulfur colloid and 500 ml 10% glucose containing 111In-diethylenetriamine pentaacetic acid. Plasma CCK was measured by a specific radioimmunoassay. Loxiglumide markedly accelerated gastric emptying of both phases of the meal. The lag period was shortened by 26% (P < 0.03); the area under the emptying curve and half-emptying time of solid emptying were lowered by 19 and 24% (P < 0.02) and of liquid emptying by 18 and 24% (P < 0.04), respectively. Plasma CCK levels were higher during infusion of loxiglumide compared with placebo (P < 0.02). These data demonstrate that post-prandially released CCK is a major regulator of gastric emptying of physiological meals containing both solid and liquid components.